Effects of pregnancy on blood/gas and tissue/gas partition coefficients of fluorinated volatile anesthetics in rats
- VernacularTitle:妊娠对大鼠吸入性全麻药血／气分配系数和组织／气分配系数的影响
- Author:
Yan RAO
;
Huafeng LI
;
Yanlin WANG
- Publication Type:Journal Article
- Keywords:
Pregnancy;
Anesthetics,inhalation;
Pharmacokinetics
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine blood/gas and tissue/gas partition coefficients of sevoflurane, isoflurane and halothane and evaluate the effects of pregnancy on them. Methods Ten 18-22 day pregnant and 10 non-pregnant SD rats were killed under pentobarbital anesthesia. The tissue specimens of heart, liver, kidney and brain were obtained and made into homogenates respectively. The blood/gas and tissue/gas partition coefficients of sevoflurane, isoflurane and halothane were determined using a method of 2-stage headspace equilibration by gas chromatography. Results Blood/gas and brain/gas partition coefficients were lower in pregnant group than in non-pregnant group (P
