Effects of aerosolized prostaglandin E_1 inhalation on oxygenation and intrapulmonary shunt in a porcine model of acute lung injury
- VernacularTitle:雾化吸入前列腺素E_1对急性肺损伤猪氧合及肺内分流的影响
- Author:
Ziyong YUE
;
Chunyu SONG
;
Wenzhi LI
- Publication Type:Journal Article
- Keywords:
Alprostadil;
Respiratory distress syndrome,adult;
Oxygen;
Hemodynamic phenomena;
Pulmonary circulation
- From:
Chinese Journal of Anesthesiology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of aerosolized prostaglandin E1 (PGE1) inhalation on oxygenation and intrapulmonary shunt in acute lung injury (ALI) .Methods Eighteen healthy male pigs weighing 14-18 kg were anesthetized with intraperitoneal pentobarbital 50 mg?kg-1, intubated and mechanically ventilated (VT=10-15 ml?kg-1, RR= 16 bpm, FiO2=100%) . PaCO2 was maintained at 34-45 mm Hg. Anesthesia was maintained with intravenous infusion of ketamine-procaine-succinyl-choline. Swan-Ganz catheter was placed via right femoral vein. Right femoral artery was cannulated for BP monitoring and blood sampling. ALI was induced by intratracheal instillation of HCl (0.1 mol?L-1) until PaO2 was
