Relationship between angiotensin converting enzyme gene insertion/deletion polymorphism and the severe morbidity of neonates
- VernacularTitle:血管紧张素转化酶基因插入或缺失多态性与新生儿危重症关系的研究
- Author:
Tongyan HAN
;
Hongmao YE
;
Xinli WANG
- Publication Type:Journal Article
- Keywords:
Peptidy-dipeptidase A;
Polymorphism (genetics);
Fetal blood
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and the severe morbidity of neonates. Methods According to the Neonatal Critical Score (draft), neonates were divided into three groups:control group (n=116), non-critical group (n=237) and critical group (n=98). ACE genotype was determined by PCR. Results The DD genotype was significantly higher in critical group compared with the other two. The critical score on first day of hospitalization was significantly lower in DD genotype than ID or II (93.52?6.99 vs 96.43?5.80 and 96.22?6.41, P
