Effects of oxidative stress in the pathogenesis of lung injury and the influence of N-acetylcysteine
- VernacularTitle:氧化应激在高氧肺损伤发生中的作用及N乙酰半胱氨酸的干预效果
- Author:
Xin XIAO
;
Xiuxiang LIU
;
Xiaoguang ZHOU
- Publication Type:Journal Article
- Keywords:
Hyperoxia;
Lung diseases;
Acetylcysteine;
Isoprostanes;
Oxidative stress
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of oxidative stress in the pathogenesis of lung injury and observe the influence of N-acetylcysteine (NAC). Methods The lung histopathology was observed by light microscope. The level of 8-iso-prostaglandin F2?lpha (8-iso-PGF2?) in blood plasm were measured by ELISA. The difference of 8-iso-PGF2? in blood plasm in air group, different dose NAC groups between hyperoxia-model and the air group was compared. Results In hyperoxia-model group, the inequality of size of lung alveoli, hemorrhage and inflammatory cell infiltration in lung alveoli were observed on the 3rd and 7th day. The alveolar septum was thick in the hyperoxic-damaged lungs on the 14th and the 21st day. In hyperoxia+high-dose NAC group, very small amounts of red blood cells leaked out into alveoli on the 3rd and 7th day and alveolar septum had no thickening obviously on the 14th day and the 21st day. The level of 8-iso-PGF2? in blood plasm in hyperoxia-model group [(28.33?5.57) pg/ml, (51.21?15.01) pg/ml, (84.54?14.85) pg/ml and (43.14?11.37) pg/ml at every time points] was higher than that of the air group and hyperoxia+high-dose NAC group(P
