Celecoxib induces apoptosis in COX-2 non-expression gastric cancer cells
- VernacularTitle:塞来昔布诱导不表达环氧合酶-2的胃癌细胞凋亡研究
- Author:
Ruiping PANG
;
Pinjin HU
;
Zhirong ZENG
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Celecoxib;
Prostaglandin-endoperoxide synthase;
MGC-803 cells;
Apoptosis
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate whether celecoxib induces gastric cancer cell apoptosis in a COX-2 non-expression cell line.METHODS: The COX-2 protein was examined by western blotting.Fluorescence microscopy,DNA agarose gel electrophoresis and flow cytometry analysis were used to test apoptosis.RESULTS: COX-2 was expressed in AGS but not MGC-803 gastric cancer cell line;Selective COX-2 inhibitor celecoxib induced MGC-803 cell line apoptosis in a concentration and time-dependent manner.CONCLUSION: Celecoxib induces apoptosis in COX-2 non-expression gastric cancer cells.
