Cytotoxicity of effector cells targeting tumor cells mediated by monoclonal antibody AU_(14-1) against experimental uterine cervical carcinoma
- VernacularTitle:宫颈癌单克隆抗体AU_(14-1)介导效应细胞对靶细胞的细胞毒
- Author:
Hongmei WANG
;
Shuyun WU
;
Fangyun XU
;
Gansheng WEN
- Publication Type:Journal Article
- Keywords:
Antibodies,monoclonal;
Cervix neoplasms;
U_(14) cells
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of monoclonal antibody(McAb) AU_(14-1) mediated cytotoxicity against cervical cancer U_(14) cell in vitro.METHODS: MTT colorimetric assay was applied to study the McAb AU_(14-1) mediated cytotoxicity of effector cells including splenocytes,peritoneal macrophages and LAK to U_(14) cells.RESULTS: The cytotoxicity mediated by each effector cells to the U_(14) cells treated with McAb AU_(14-1) was significantly higher than those not treated with it(P
