Inhibitory effects of genistein on mouse allergic contact dermatitis
- VernacularTitle:染料木黄酮抑制小鼠变应性接触性皮炎的实验研究
- Author:
Lin CONG
;
Yaoying ZENG
;
Xiaochang CAI
;
Min YI
;
Jun SHI
- Publication Type:Journal Article
- Keywords:
Dermatitis,allergic contact;
Genistein
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the inhibitory effects of genistein(Gen) on mouse allergic contact dermatitis(ACD).METHODS: The animal model of ACD was induced by DNFB.The effects of different doses of Gen on mouse ear swelling,body weight,histopathological changes in mouse ear skin,thymus index and spleen index were observed.RESULTS: All groups of Gen inhibited mouse ear swelling induced by DNFB significantly.The infiltration of inflammatory cells and thymus index were also reduced.However,the increase in mouse body weight was not affected.Low dose of Gen increased spleen index,high dose of Gen decreased spleen index.CONCLUSION: Genistein has significant inhibitory effects on mouse ACD induced by DNFB.
