Chronic cigarette smoking induces alteration of FIZZ1/RELM? expression in rat lung
- VernacularTitle:慢性吸烟大鼠肺组织FIZZ1/REL M?表达的变化
- Author:
Hong YE
;
Wanli MA
;
Shaohua ZHANG
;
Qing XU
;
Shiou FU
;
Shengyuan LIU
;
Dixun WANG
- Publication Type:Journal Article
- Keywords:
Smoking;
Airway;
Lung;
Genes,FIZZ1/RELM?
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the expression of FIZZ1/RELM? in lung tissue of chronic cigarette smoking rat,and to determine the relationship between airway inflammation and airway hyperresponsiveness.METHODS: Made rat model of chronic cigarette smoking was used.The expression of FIZZ1/RELM? in lung tissue was determined by immuno-histochemistry and in situ hybridization.RESULTS: In control rats,FIZZ1/RELM? protein and mRNA expressions were observed at low levels.In cigarette smoking rats,FIZZ1/RELM? expression increased in all the cells especially in bronchial smooth muscle cells,vascular wall cells and alveolar epithelial cells.CONCLUSION: FIZZ1/RELM? is a secreted peptide specifically expressed in lung.Cigarette smoking induces its upregulation,which possibly contributes to cigarette smoking-induced airway hyperresponsiveness.
