HLA-DRB1 genotyping and its relation with chronic HBV infection in patients
- VernacularTitle:慢性乙型肝炎病毒感染与HLA-DRB1基因的相关性研究
- Author:
Guitao YANG
;
Jie LIU
;
Dezhong XU
;
Yongping YAN
;
Huahong XIE
;
Yulei DU
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Genes,HLA-DRB1;
Genotype
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the HLA-DRB1 genotype and their relation with HBV infection in Shaanxi Han patients.METHODS: HLA-DRB1 genotyping was conducted in 108 case of chronic HBV infection and 108 health controls as well as 32 asymtomatic HBsAg carriers by using polymerase chain reaction-sequence specific primer method.All the patients,asymtomatic HBsAg carriers and health subjects were residents of Shaanxi district and belonged to Han nationality.The association between HLA-DRB1 genotype and different replication of HBV was also studied.RESULTS: DRB1~*04,DRB1~*09,DRB1~*12 and DRB1~*15 were the most common genotypes in Shaanxi Han residents with the frequency of 16.2%,12.5%,11.6% and 13.4%,respectively.Compared to 108 health controls,the allele frequency of HLA-DRB1~*03(10.6% of HBV patients versus 3.7% of health controls,odds ratio=3.10;P
