Change of serum osteocalcin level in the bone transplantation
- VernacularTitle:不同预处理方式的大块异体骨移植血清骨钙素的变化及意义
- Author:
Song JIN
;
Jingnan SHEN
;
Junqiang YIN
;
Changye ZOU
- Publication Type:Journal Article
- Keywords:
Bone transplantation;
Osteocalcin;
Radioimmunoassay
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To detect serum osteocalcin level during bone transplantation.METHODS: The animal model of the dog's bone transplantation was established.15 dogs were randomly divided into three groups: irradiation,non-irradiation and bone morphogenetic protein(BMP)-adding group.The allografts bones were treated by cryopreservation and lyophilization,respectively.The animal models were constructed by resecting 2 cm diaphysis and periosteam from the middle pane of both radius of the dogs and transplantation bone were fixed by triargle needle.X-ray examination was taken on the operating day and 1 month,3 months,5 months after operation,respectively.The serum osteocalcin level was detected preoperation,2 weeks,4 weeks,6 weeks,8 weeks and 10 weeks after operation.RESULTS: The level of serum osteocalcin significantly changed in the bone transplantation before and after operation.BMP made an effect on the changes of BGP.CONCLUSIONS: Serum osteocalcin is a peculiar sensitive and convenient biochemical index that reflects metabolism of bone transplantation.More over,it has some importance for differently processed allografts of bone.BMP increases the content of BGP in the serum and accelerates the bone formation.
