Antihypoxic Effect of Orientoside on Hypoxia Model Mice
- VernacularTitle:荭草苷对缺氧模型小鼠的抗缺氧作用研究
- Author:
Xiaochun FU
;
Weifen QIU
;
Xi WANG
- Publication Type:Journal Article
- Keywords:
Orientoside;
Mouse;
Hypoxia model;
Anti-hypoxic effect
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the antihypoxic effect of orientoside on hypoxia model rats.METHODS:The hy-poxia rats model was established through normobaric hypoxia,poisoning with sodium nitrite,potassium cyanide and lidocaine,trachea occlusion,decapitation,etc.20minutes prior to the modeling,the rats were administered with the corresponding drugs with the anti-hypoxic effects observed.RESULTS:As compared with placebo group,the survival time of rats under nor-mobaric hypoxia,poisoned by sodium nitrite,potassium cyanide and lidocaine,and the electrocardiograph extinction time after trachea occlusion and the gasping time of mice after decapitation were all significantly prolonged by orientoside.CONCLU-SION:Orientoside has antihypoxic effect on hypoxia model rats.
