Depressant effect of atorvastatin on arteriosclerosis of aortic allograft in rats
- VernacularTitle:阿托伐他汀对移植动脉硬化抑制作用的实验研究
- Author:
Xingjun GUO
;
Qichang ZHENG
;
Zifang SONG
;
Lei ZHANG
;
Keqiang ZUO
;
Wenbo KE
- Publication Type:Journal Article
- Keywords:
Arteris/transpl;
Atorvastatin/ther use;
Gene Expression;
Models,Animal
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the depressant effect of atorvastatin on arteriosclerosis of aortic allograft in rats.Methods The models of abdominal aorta transplantation were established in rats with the use of(micro-surgery).The recipients were divided into three groups:allograft control group,allograft experimental group and isograft control group.After 60 days of transplant,vascular intimal thickness(VIT) in all of the groups was observed by histological examination.The expression of PCNA and ?-SMA was determined by(immunohistochemistry).Results The degree of VIT in rats of the allograft experimental group was lower than that in the allograft control group;the VIT area ratio in the allograft control group,allograft experimental group and isograft control group was(12.40?2.65)%,(5.20?6.35)%,and(1.2?1.10)%,respectively,A statistical difference between these groups was observed(P
