Effects of selective cyclooxygenase-2 inhibitor Celebrex on the growth of gallbladder carcinoma GBC-SD cell line
- VernacularTitle:选择性Cox-2抑制剂Celebrex对人胆囊癌GBC-SD细胞系生长的抑制作用
- Author:
Xiaoshu RUAN
;
Renyi QIN
- Publication Type:Journal Article
- Keywords:
Gallbladder Carinoma GBC-SD Cell Line;
Cyclooxygebase/antay
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of cyclooxygenase-2 inhibitor Celebrex on the growth of(gallbladder) carcinoma GBC-SD cell line.Methods Cell growth suppression was counted by MTT method.Apoptotic index(AI) was evaluated by TUNEL staining.The apoptotic rate was counted by flow cytometry(FCM),fluorescence microscopy(FM) and transmission electron microscopy(TEM).Results Celebrex(inhibiting) the growth of GBC-SD cell line was dose-depend.The growth inhibition rate with 40?mol/L,80?mol/L,120?mol/L and 160?mol/L was 18.77%,25.32%,46.58% and 52.19%(respectively),(P
