Effects of Dantrolene on the Interaction of Calcium and Erythrocyte Membrane.
10.3349/ymj.1987.28.4.249
- Author:
Bok Soon KANG
1
Author Information
1. Department of Physiology, Yonsei University College of Medicine Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Red blood cell;
calcium transport;
Ca++-ATPase activity;
calcium binding;
dantrolene sodium
- MeSH:
Calcium/metabolism*;
Dantrolene/pharmacology*;
Erythrocyte Membrane/drug effects*;
Erythrocyte Membrane/metabolism;
Human;
Ion Channels/drug effects*;
Ion Channels/metabolism
- From:Yonsei Medical Journal
1987;28(4):249-254
- CountryRepublic of Korea
- Language:English
-
Abstract:
Dantrolene sodium in vitro inhibited the ATP-dependent efflux of calcium from human Fed cells, the Ca++-ATPase activity of red blood cell membrane fragments (RBCMF) and passive calcium binding to RBCMF. These effects were obtained With concentrations of dantrolene sodium between 2.5 and 20 uM. However the passive influx of Ca++ was measured at 37 degrees C in cells pretreated to abolish Ca++ pumping and was not influenced by dantrolene sodium. From these results, it was concluded that dantrolene sodium inhibits an active Ca++ extrusion across the red cell membrane by inhibiting Ca++-ATPase activity which is intimately involved with the Ca++ transport mechanism in the red cell membrane.
