High Activities of Protein Kinases C and M in Fresh Human Stomach and Breast Tumors.
10.3349/ymj.1987.28.4.255
- Author:
In Kyoung LIM
1
;
Do Jong LEE
;
Kee Ho LEE
;
Taik Koo YUN
Author Information
1. Laboratory of Biochemistry, Korea Cancer Center Hospital, Korea Advanced Energy Research Institute, Seoul, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
PKC and PKM activities;
c-myc and c-fos expression;
human stomach and breast cancer
- MeSH:
Adenocarcinoma/enzymology*;
Breast Neoplasms/enzymology*;
Carcinoma, Intraductal, Noninfiltrating/enzymology*;
Human;
Protein Kinase C/metabolism*;
Stomach Neoplasms/enzymology*
- From:Yonsei Medical Journal
1987;28(4):255-260
- CountryRepublic of Korea
- Language:English
-
Abstract:
The activities of Ca+2-PL dependent protein Kinase (PKC) and independent protein kinase(RKM) were measured in human stomach and breast tumors and in the respective counterparts of normal tissue. Expression of c-fos and c-myc of the tissues were also measured. RNAs of c-fos and c-myc were unexpectedly high in the tissue from normal stomach and breast as well as in all cancer tissue. On the other hand, cytosolic and particulate PKC activities were higher in the tumors as compared to those of normal controls. Notably, some cases exhibited. altered activities of PKC i.e. increased RKM activities as high as RKC, which might be related to the autocrine control of growth in the tumor mass.
