Protective effects and mechanism of Pentoxifylline on rats with renal interstitial fibrosis following unilateral ureteral obstruction
- VernacularTitle:己酮可可碱对单侧输尿管梗阻大鼠肾间质纤维化的保护作用及其机制
- Author:
Shuxia FU
;
Xiqian WANG
;
Yujie HAO
;
Lin YANG
- Publication Type:Journal Article
- Keywords:
Pentoxifylline;
Glomerulosclerosis,focal;
Vascular endothelial growth factors;
Bone morphogenetic proteins;
Transforming growth factor beta;
NF-kappa B;
Tissue inhibitor fo metalloproteinases
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects and mechanism of Pentoxifylline(PTX) on rats with renal interstitial fibrosis following unilateral ureteral obstruction(UUO).Methods The rats were randomly divided into 5 groups: Sham operation group(group A),UUO group(group B),Enalapril group(group C),PTX group(group D) and PTX plus Enalapril group(group E).On the 3th,7th and 14th day after operation,5 rats of each group were sacrificed by exsanguinations,respectively.The concentration of hydroxyproline was measured,and the ratio of collagen and renal weight was tested.The expressions of transforming growth factor-?1(TGF-?1),tissue inhibitor of metalloproteinase-1(TIMP-1),vascular endothelial growth factor(VEGF),bone morphogenetic protein-7(BMP-7),NF-?B and CD34 were measured by immunohistochemistry.The peritubular capillary index(PCI) was regarded as the expression of CD34.Results The ratio of collagen and renal weight in the rats of group B was higher than that of other 4 groups(P
