Expressions of nuclear factor-kappa B and monocyte chemoattractant protein-1 in renal tissue of uric acid nephropathy rats and their significance
- VernacularTitle:核因子-?B与单核细胞趋化因子-1在尿酸性肾病大鼠肾脏中的表达及意义
- Author:
Fengping LIN
;
Kaiming REN
;
Enfeng SONG
;
Jiacai HU
;
Fan WU
- Publication Type:Journal Article
- Keywords:
NF-kappa B;
Monocyte chemoattractant proteins;
Kidney diseases;
Uric acid
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of nuclear factor-kappa B(NF-?B) and monocyte chemoattractant protein-1(MCP-1) in the pathogenesis of uric acid nephropathy.Methods Twenty male SD rats were divided into control group(group C) and model group(group M).The model rats with uric acid nephropathy were made using adenine.Immunohistochemistry was used to detect the expressions of NF-?B and MCP-1 in 18 days and the serum uric acid and renal fuction were measured respectively.Results In comparison with group C,the expressions of NF-?B and MCP-1 in the rats of group M were significantly increased(all P
