Effects of aspirin on the expression of transforming growth factor?1 in the kidney of diabetic rats
- VernacularTitle:阿斯匹林对大鼠糖尿病肾转化生长因子-?_1表达的影响
- Author:
Yinhong HUANG
;
Xiaocheng LIU
- Publication Type:Journal Article
- Keywords:
Aspirin;
Diabetic nephropathies;
Transforming growth factor beta
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of aspirin on renal lesions in diabetic rats.Methods The model of diabetic rats was induced by streptozotocin.The diabetic rats were treated with 10 mg?kg~(-1)?d~(-1) aspirin for 6 weeks.The urinary albumin excretion and creatinine clearance(Ccr) were tested.The expression of TGF-?1 in renal cortex of diabetic rats was determined by immunohistochemical staining.Results The Ccr was decreased in diabetic rats with the treatment of aspirin for 6 weeks and the urinary albumin excretion was not obviously decreased.The immunohistochemical staining of TGF-?1 in aspirin-treated group was significantly decreased than that of the control group(P
