Protective effects of 3-aminobenzamide on kidney in diabetic rats
- VernacularTitle:PARP抑制剂对早期糖尿病大鼠肾脏的保护作用
- Author:
Wei GUO
;
Muxun ZHANG
- Publication Type:Journal Article
- Keywords:
Benzamides;
Diabetic nephropathies
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of 3-aminobenzamide on the kidney of STZ-induced diabetic rats.Methods Experimental rats were divided into normal control group(group NC),diabetic control group(group DC) and diabetic rats treated with 3-aminobenzamide(group DT).The indexes such as the creatinine clearance rate(Ccr),the ratio of kidney weight to body weight,the contents of blood glucose,24h urinary protein,malonaldehyde(MDA),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px) were tested in each group after 4 weeks.The expression of PARP was tested by immunohistochemistry method.Results Compared with group DC,the 24h urinary protein,Ccr and the concentration of MDA were decreased in group DT,as well as the activity of SOD and GSH-Px was enhanced(all P
