Effects of fluvastatin on NF-?B activity and osteopontin mRNA expression in albumin-induced renal tubular epithelial cells
- VernacularTitle:氟伐他汀对白蛋白诱导肾小管上皮细胞内NF-?B活性及OPNmRNA表达的影响
- Author:
Qinghong ZHANG
;
Jiane ZHANG
;
Guohua DING
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Pravastatin;
Albumins;
Kidney tubules;
NF-kappa B;
Sialoglycoproteins
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of fluvastatin on NF-?B activity and osteopontin(OPN) mRNA expression in albumin-induced renal tubular epithelial cells.Methods The renal tubular epithelial cells were cultured with 30 mg/ml fat free bovine serum albumin(BSA) as the control group.The renal tubular epithelial cells in the treatment group were cultured with different concentrations of fluvastatin for different hours.EMSA and RT-PCR were used to observe NF-?B activity and OPNmRNA expression.Results Fluvastatin can inhibit the NF-?B activity and OPNmRNA expression in a time and dose dependent manner.Conclusion Fluvastatin can inhibit NF-?B activity and OPNmRNA expression in albumin induced tubular epithelial cells.
