Effects of tetramethylpyrazine on the expression of nuclear factorkappa B induced by advanced glycation end products in retinal pigment epithelium
- VernacularTitle:川芎嗪对糖基化终产物诱导人视网膜色素上皮细胞表达核因子-?B的影响
- Author:
Zhongping CHEN
;
Deyong JIANG
;
Xiaojiang GUO
;
Luosheng TANG
;
Xiaohua ZHU
- Publication Type:Journal Article
- Keywords:
Tetramethylpyrazine;
Glycosylation end products,advanced;
Pigment epithelium of eye;
NF-kappa B
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of tetramethylpyrazine(TMP) on the expression of nuclear factor-kappa B(NF-?B) induced by advanced glycation end products(AGEs) in retinal pigment epithelial(RPE).Methods The expressions of NF-?B were detected by immunohistochemical method when the RPE cells were cultured with different concentrations of AGEs in different time points.Results With the increasing of concentrations of AGEs,the expression of NF-?B in RPE was increased gradually.The expression of NF-?B in RPE was higher when the cells were cultured with AGEs for 24 h than that of other time points.With the increasing of the concentration of TMP,the expression of NF-?B in RPE was decreased gradually.Conclusion The AGEs can induce the expression of NF-?B in RPE,and the TMP can prevent the effects of AGEs in a concentration dependent manner.
