Study of the association between ?3 adrenergic receptor gene Trp~(64) Arg mutation and type 2 diabetes
- VernacularTitle:?3肾上腺素能受体基因Trp~(64) Arg突变与胰岛素抵抗相关
- Author:
Li LI
;
Liming SUN
;
Jun WANG
;
Yanhu DONG
;
Yuanguo SI
- Publication Type:Journal Article
- Keywords:
Receptors,adrenergic;
Mutation;
Insulin resistance
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between ?3 adrenergic receptor(?3AR) gene Trp~(64)Arg mutation and insulin resistance(IR) in Chinese.Methods The 120 patients with type 2 diabetes mellitus(group DM) and 80 nondiabetic subjects as normal controls(group N)were involved in the study.Polymerase chain reaction(PCR) and the restriction fragment length polymorphism analysis(PCR-RFLP) were used to determine the ?3AR genotype.The indexes such as body weight,height,waist circumstance,hip circumstance,blood pressure,lipids,fast plasma glucose and insulin were detected in all subjects.The IR was estimated by homeostasis model assessment(HOMA-IR).The patients in the diabetes group were divided into relative insulin sensitive group and relative insulin resistant group by the 75th percentile HOMA-IR.Results The BMI of the patients with the ?3AR Trp~(64)Arg mutation was significantly higher than that of those without the mutation(P
