Expression of Survivin and Caspase-3 protein and their relationships with apoptosis in colorectal carcinoma
- VernacularTitle:Survivin和Caspase-3在大肠癌中的表达及其与细胞凋亡的关系
- Author:
Huijun TIAN
;
Dile WANG
- Publication Type:Journal Article
- Keywords:
Intestinal neoplasms;
Cysteine proteinases;
Gene expression;
Apoptosis
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expressions of Survivin and Caspase-3 in patients with colorectal carcinoma and their association with tumor cell apoptosis.Methods The TdT-mediated dUTP nick end labelling(TUNEL) and immunohistochemistry were used to study cell apoptosis and expression of Survivin and Caspase-3 in 68 cases of colorectal cancer tissues and 20 normal controls.Results Survivin was expressed in 36 of 68(52.9%) cases of colorectal carcinoma and was not expressed in normal tissues.The expression of Survivin was significantly correlated with lymph node metastasis and histological type(P
