Link of autoantibodies against ?_1 receptor with hypertension-related renal failure
- VernacularTitle:?_1肾上腺素受体自身抗体在高血压肾损害致病机制的初步探讨
- Author:
Linshuang ZHAO
;
Yuhua LIAO
;
Min WANG
;
Zihua ZHOU
;
Guangda XIANG
;
Jie HOU
;
Ling LE
;
Lin XU
- Publication Type:Journal Article
- Keywords:
Hypertension with renal failure;
Receptors;
Autoantibodies
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of the autoantibodies against ?_1-adrenergic receptor(?_1-receptor)in the development of hypertension with renal failure.Methods The epitopes of the second extracellular loop of ?_1-receptor were synthesized and used respectively to screen sera autoantibodies from patients with hypertension with renal failure(61 cases),hypertension without renal failure(58 cases) and healthy blood donors(40 cases,control) by ELISA method.Results The positive rates of the autoantibodies ?_1-receptor(69%,42/61) in patients with hypertension with renal failure were higher than those of patients with hypertension without renal failure(19%,11/58) respectively(P
