A Study on the Correlation between Exon 5 Polymorphism of Glutathione S-transferase P1 Gene and Clinic Phenotype of COPD
- VernacularTitle:GSTP1第5外显子多态性与COPD关系研究
- Author:
Lizhou FANG
;
Jianqing ZHANG
;
Zhihuan ZHAO
;
Ling LIU
;
Weiping FU
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
GSTP1;
Polymorphism;
Clinic phenotype;
CT
- From:
Journal of Kunming Medical University
1990;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between GSTP1 exon5 A/G polymorphism and clinic phenotype of COPD in the population of the Han nationality from southwest China.Methods Using PCR followed by restriction fragment length polymorphism(PCR-RFLP),genotypes of Ile105Val polymorphism in exon5 of GSTP1 were determined in 91 patients with COPD and 87 healthy control subjects.Results No significant differences were observed in the frequencies of genotypes and alleles of exon5 of GSTP1 between COPD patients and the healthy controls.The frequency of Ile105 in pink puffer patients was much more than that in the blue bloater patients.The CT scores of emphysema in patients with Ile105 was significantly higher than those with Val105.Conclusions The genetic polymorphism of exon5 of GSTP1 may not be associated with the susceptivity of COPD in the populations of the Han nationality from southwest China,but may be correlated with clinical phenotypes and lung parenchyma damage of COPD patients in the present population.
