A Study on the Correlation of Calpain 10 Gene SNP44 Polymorphism with Genetic Susceptibility to Type 2 Diabets in Kunming
- VernacularTitle:昆明地区人群Calpain10基因SNP44变异与2型糖尿病遗传易感性的关联研究
- Author:
Jun QIU
;
Maorong ZHANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Site SNP44 of Calpain10 gene;
Case-control study;
Polymorphism;
Genetic susceptibility
- From:
Journal of Kunming Medical University
1990;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of single nucleotide polymorphism-SNP44 of Calpain 10 gene with genetic susceptibility to type 2 diabetes in Kunming.Methods The polymorphism of site UCSNP44(T/C) in Calpain 10 gene was detected by Polymerase chain reaction and Allele specific amplification(PCR-ASA)in 131 type 2 diabetic patients and 131 non-diabetic controls who were selected using case-control study in the Kunming urban communities.Results The frequency of"C"allele and"TC"gene of SNP44 in type 2 diabetic patients was significantly higher than that in the controls.Conclusion The study suggested that the polymorphism-SNP44 of Calpain10 gene may be associated with genetic susceptibility to type 2 diabetes in Kunming population.
