Expression of TSP mRNA and its relation with angiogenesis and lymph node metastasis in papillary thyroid carcinoma
- VernacularTitle:血小板反应素mRNA表达与甲状腺乳头状癌血管生成、转移的关系
- Author:
Yunzong LIAN
;
Jianliang ZHUANG
;
Yifeng CHEN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Carcinoma,papillary;
Reagins;
Neovascularization,pathologic;
Lymphatic metastasis
- From:
International Journal of Laboratory Medicine
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of thrombospondin(TSP) mRNA and its relationship with angiogenesis and lymph node metastasis in papillary thyroid carcinoma(PTC).Methods RT-PCT was utilized to detect the expression of TSP1 and TSP2 mRNA in 40 cases of PTC and 10 cases of normal tissue surrounding carcinoma.Immunohistochemical stain was performed to detect microvessel density(MVD) whose endothelia were marked by anti-CD105 McAb.Results The positive-expression rate of TSP1 mRNA,TSP2 mRNA was 80.0%,90.0% respectively in normal tissue surrounding carcinoma.The positive-expression rate of TSPI mRNA was 45.0%.The positive-expression rate of TSP2 mRNA was 47.5%.The MVD value of PTC cases with TSP1 and TSP2 mRNA positive expression was significantly lower than that of cases without TSP1 and TSP2 mRNA expression(P
