Observation on Preventive Effect of Ca/Mg Infusion Combined with Glutathione and Carbamazepine on Oxaliplatin-induced Neurotoxicity
- VernacularTitle:钙镁合剂联合谷胱甘肽和卡马西平预防奥沙利铂神经毒性疗效观察
- Author:
Jiewen PENG
;
Hanlin LIANG
;
Junkai ZHANG
;
Jianjun XIAO
;
Chaozhen ZHANG
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Neurotoxicity;
Glutathione;
Carbamazepine;
Calcium;
Magnesium
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the preventive effect of Ca/Mg infusion combined with glutathione and carbamazepine on oxaliplatin-induced neurotoxicity.METHODS:65patients treated with oxaliplatin,5-fluorouracil and leucovorin for gas-trointestinal cancer were divided into treatment group undergoing treatment with Ca/Mg infusion combined with glutathione and carbamazepine,and control group without any preventive treatment.RESULTS:At the third cycle,7patients in the treat-ment group but17patients in the control group showed clinically evident neurotoxicity,which demonstrated the statistical difference between the two groups(P=0.036).After12cycles,neurotoxicity of grade2to3was observed in2patients in the treatment group but in9patients in the control group,which demonstrated the statistical difference between the two groups(P=0.022).CONCLUSION:Ca/Mg infusions combined with glutathione and carbamazepine can prevent oxaliplatin-induced neurotoxicity.
