Determination of Principal Agent in Oxiracetam Sodium Chloride Injection by HPLC
- VernacularTitle:高效液相色谱法测定奥拉西坦氯化钠注射液中主药的含量
- Author:
Xiaoyan YAN
;
Xin HU
;
Guoying CAO
- Publication Type:Journal Article
- Keywords:
HPLC;
Oxiracetam sodium chloride injection;
Contents
- From:
China Pharmacy
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To develop a HPLC method for the assaying of the principal agent in oxiracetam sodium chloride injection.METHODS:The separation was performed on Intersil CN-3column;the mobile phase was a mixture of acetonitri_ le-water(6∶94)with detection wavelength at214nm,flow rate at0.6ml/min and sample size at5?l under room temperature. RESULTS:The linear correlation of oxiracetam was observed over the concentrations of0.5625to288?g/ml(r=0.9999).The average recovery was99.95%(RSD=1.36%).CONCLUSION:The method is accurate,convenient specific and repro-ducible,and suitable for the determination and quality control of Oxiracetam.
