The study on the association of the interleukin-4 receptor gene polymorphism with allergic rhinitis
- VernacularTitle:白细胞介素4受体基因多态性与变应性鼻炎的相关性
- Author:
Jing MA
;
Chao DONG
;
Ying ZHANG
;
Xiaojiang LI
;
Biao RUAN
;
Jun SUI
- Publication Type:Journal Article
- Keywords:
Receptors,Interleukin-4;
Rhinitis,Allergic,Perennial;
Polymorphism,Restriction Fragment Length;
Genotype
- From:
Chinese Archives of Otolaryngology-Head and Neck Surgery
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To dectect the possible association between interleukin-4 receptor gene polymorphism and allergic rhinitis. METHODS The study was conducted in two different groups: patients with allergic rhinitis (the case group,n=50) and healthy people (the control group,n=40). The IL-4R Q576R polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The study compared frequencies distribution of genotype and allele between the two groups,and calculated odds ratio (OR) of genotype. RESULTS IL-4R allelic frequencies showed significant difference between the two groups (x2=9.12,P
