Comparison of Wound Repair after Irradiation of Rat Skin with 1064 nm Nd:YAG, CO2, and Er:YAG Lasers.
- Author:
Hyun Jo KIM
1
;
Gang Mo LEE
;
Young Lip PARK
;
Jong Suk LEE
;
Kyu Uang WHANG
;
Sung Yul LEE
Author Information
1. CNP Skin Clinic, Cheoan, Korea.
- Publication Type:Original Article
- Keywords:
1064 nm Q-switched Nd:YAG laser;
CO2 laser;
Er:YAG laser;
Wound repair;
Non selective tissue heat damage;
Sprague Dawley(R)
- MeSH:
Animals;
Biopsy;
Dermatology;
Dermis;
Epidermis;
Hot Temperature;
Laser Therapy;
Lasers, Gas;
Rats*;
Skin*;
Wounds and Injuries*
- From:Korean Journal of Dermatology
2014;52(4):244-251
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Laser therapy for various skin conditions is one of the most common procedures in dermatology. Recently, several articles described the use of 1064 nm Q-switched Nd:YAG lasers for the treatment of benign skin lesions. Such treatment is known to trigger its therapeutic effect through a photoacoustic effect and selective photothermolysis effect. However, only a limited number of articles have dealt with the theoretical base of the photoacoustic effect of the 1064 nm Q-switched Nd:YAG laser. OBJECTIVE: To compare the wound repair process and nonselective tissue heat damage induced by three different laser modalities: the CO2 laser, Er:YAG laser, and 1064 nm Q-switched Nd:YAG laser. METHODS: We irradiated the skin of an albino rat (Sprague Dawley(R), 200~250 g) with CO2, Er:YAG, and 1064 nm Q-switched Nd:YAG lasers. Skin biopsy specimens of the irradiated areas were collected on the first, fifth, and tenth day after laser exposure. For histologic analysis, the specimens were stained with the H&E, Verhoff-Van Gieson, and Masson's trichrome protocols. RESULTS: Compared with other laser modalities, rat skin irradiated by the 1064 nm Q-switched Nd:YAG laser showed the least amount of heat damage and the quickest tissue repair response to the damage. CONCLUSION: A 1064 nm Q-switched Nd:YAG laser with a photoacoustic effect capable of ablating the epidermis and dermis can be a proper treatment modality for the removal of benign skin lesions. The 1064 nm Q-switched Nd:YAG laser may be considered as an alternative treatment option for the treatment of benign skin lesions.
