Expression of apoptosis and gene proteins in gallbladder neoplasms and dysplasia
- VernacularTitle:原发性胆囊癌组织中细胞凋亡及相关基因蛋白产物的表达
- Author:
Yun FENG
;
Juhui ZHAN
;
Zhenglun QIU
;
Lian ZHANG
;
Hui GAO
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Apoptosis;
p21~ WAF1;
Bcl-2
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of apoptosis and related gene p21WAF1 and Bcl-2 in the tumorigenesis of primary gallbladder neoplasms. Methods p21WAF1 and Bcl-2 were detected by immunohistochemistry and apoptotic cells were stained in situ by terminal deoxynucleotidyl transferase mediated-dUTP nick end labeling(TUNAL) in 46 cases of primary gallbladder neoplasms with different histological grades. Results Apoptotic index and p21WAF1 were decreased,but the expression of Bcl-2 was increased with the increasing of the histological grades in primary gallbladder neoplasms (P
