The correlation between VEGF-C and COX-2 expression in human rectal cancers and its role in lymph node metastasis
- VernacularTitle:COX-2与VEGF-C在直肠癌中的表达及其在淋巴转移中的意义
- Author:
Suikuan GAO
;
Zhanbing LIU
;
Yimo YANG
;
Jianxun ZHAO
;
Xin WANG
;
Yucun LIU
;
Yuanlian WAN
;
Wenhuai XU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Lymphatic metastasis;
VEGF-C;
COX-2
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between VEGF-C and COX-2 expression in human rectal cancers and its significance in cancer metastasis. Methods VEGF-C expression was detected with Western blot in LOVO cells treated with NS-398 or PGE2. VEGF-C and COX-2 expression in 45 rectal adenocarcinomas was tested with immunohistochemistry. Results NS-398 inhibited the VEGF-C expression, and PGE2 up-regulated the expression of VEGF-C in a dosage-dependent way in LOVO cells. VEGF-C expression was significantly higher in adenocarcinomas with lymph node metastasis, and was related with the expression of COX-2 in 45 rectal adenocarcinomas. Conclusion COX-2 up-regulates VEGF-C and VEGF-C plays an important role in lymphatic metastasis of rectal cancers.
