The expression of?-catenin in human colorectal cancer and its biological significance
- VernacularTitle:?-catenin在结直肠癌中的表达及生物学意义
- Author:
Yifan PENG
;
Dalong SUN
;
Jin GU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Signal transduction;
?-catenin
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of ?-catenin protein in colorectal cancer. Methods Thirty-six CRC cases underwent radical operation from February 2001 to September 2001, ?-catenin protein expression was studied with immunnohistochemistry. ?-catenin mRNA expression was examined by reverse transcription-polymerase chain reaction (RT-PCR). The correlation between ?-catenin protein expression and CRC clinical pathological factors was studied. Results ?-catenin protein expression was positive in 30 CRC cases ( 83. 3% ) , and 2 cases ( 5. 6% ) in normal colorectal epithelium cells ( P
