Half-effective target plasma concentration of propofol for fibercolonoscope examination
- VernacularTitle:纤维结肠镜检查术患者靶控输注异丙酚的半数有效血浆靶浓度
- Author:
Qing LI
;
Jianguo XU
;
Shuyuan GAN
- Publication Type:Journal Article
- Keywords:
Propofol;
Drug delivery systems;
Colonoscopy;
Dose-response relationship,drug
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effective target plasma propofol concentration required to prevent the response to fibercolonoscope examination in 50% of patients (EC50) .Methods Sixty ASA Ⅰ or Ⅱ patients aged 18-60 yrs weighing 45-70 kg undergoing fibercolonoscope examination were enrolled in this study. The initial target plasma propofol concentration was set at 5.0 ?g?ml-1 . EC50 was determined by up-and-down sequential experiment. The effect of TCI of propofol was based on the movement on the movement of the body in response to fibercolonoscope examination. If effective the target plasma propofol concentration was set at a lower concentration in the next patient and vice sersa. Each time the target plasma propofol concentration increased/decreased by 0.5 ?g?ml-1. The up-and-down sequences were analyzed by using the Dixon and Massey method to determine the EC50.Results The EC50 of propofol for fibercolonoscope examination was 4.9 ?g?ml-1 [95% confidence interval (CI) 4.5-5.4 ?g?ml-1] . Four patients developed respiratory depression during examination (6.67%). Conclusion The EC50 of propofol for fibercolonoscope examination is 4.9 ?g?ml-1.
