Antagonistic Effect of Compound Glycyrrhizin on Bleomycin-induced Pulmonary Fibrosis of Rats
- VernacularTitle:复方甘草酸苷拮抗博莱霉素致大鼠肺纤维化的实验研究
- Author:
Yan HE
;
Guozhong DENG
;
Tian GAO
- Publication Type:Journal Article
- Keywords:
Compound glycyrrhizin;
Rats;
Antagonism;
Pulmonary fibrosis
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To observe the antagonistic effect of compound glycyrrhizin on bleomycin A5-induced pul-monary fibrosis of rats.METHODS:Pulmonary fibrosis model was built by injecting bleomycin A5to tracheas of SD rats in one time,the next day,control groups were administered with compound glycyrrhizin and prednisolone acetate,21days after administration,organ coefficients,pathology,areas of alveolar septum,areas of the inflammatory cells and the integral pho-todensity of the pulmonary tissues were detected and analyzed.RESULTS:As compared with the model group,the compound glycyrrhizin group had a diminished organ coefficient,ameliorated pathological change for pulmonary tissues and reduced areas of alveolar septum(P0.05).CONCLUSION:Compound glycyrrhizin has antagonistic effect on pulmonary fibrosis of model rats.
