Preparation and Content Determination of Lidocaine Liposome Gel
- VernacularTitle:利多卡因脂质体凝胶的制备及质量控制
- Author:
Xianxi GUO
;
Wen HE
;
Yun LUO
- Publication Type:Journal Article
- Keywords:
Lidocaine;
Liposome gel;
Preparation;
Content determination
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare lidocaine liposome gel and to establish its quality control method.METHODS:Li-docaine liposome was prepared using a film dispersion method and the liposome gels were prepared with carbomer-940as base.The concentration of lidocaine was determined by HPLC and the lipsome entrapment efficiency was determined by centrifuga-tion.RESULTS:The linear detection concentration range of lidocaine was2.5～25.0mg/ml(r=0.9996)with average re-covery at(99.83?0.53)%and entrapment efficiency at(82.7?1.83)%.CONCLUSION:This liposome gel is feasible in preparation techniques,stable in quality,convenient and reliable in quality control method.
