Relative Bioavailability of 2 Products of Loratadine Tablets in Human Body
- VernacularTitle:2种氯雷他定片剂的人体相对生物利用度试验
- Author:
Ling LIU
;
Ning JIANG
- Publication Type:Journal Article
- Keywords:
Loratadine;
Relative bioavailability;
HPLC
- From:
China Pharmacy
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To compare the relative bioavailability between2loratadine tablets(LORAX and LORAS)in human body.METHODS:22healthy male volunteers were enrolled to receive oral single dose(20mg)of either LORAX or LORAS tablets by crossover way,plasma concentrations of loratadine were determined by HPLC and pharmacokinetic param-eters were calculated by3p97program.RESULTS:The pharmacokinetic parameters of LORAX vs.LORAS were the fol-lowing,t 1/2Ke (3.03?0.98)h vs.(2.65?0.81)h;C max (8.59?6.70)vs.(9.59?8.22)ng/ml;t max (1.08?0.41)h vs.(1.21?0.28)h;AUC (0～t) (27.29?24.54)vs.(27.92?20.64)(ng?h)/ml.The relative bioavailability of LORAX was(100.63?14.27)%.CONCLUSION:2loratadine tablets were bioequivalent.
