Characterization of thyrotropin receptor molecule and its active peptide as immunogens in BALB/c mice
- VernacularTitle:TSHR大分子及其活性多肽在BALB/c小鼠体内的免疫原特性研究
- Author:
Yunjuan ZHU
;
Ning CHEN
;
Lijuan HUANG
;
Xiaomei YAO
;
Bingling SHEN
;
Jing YE
;
Yujie DAI
;
Xin LIU
;
Lijun ZHANG
;
Lanying LI
;
Fengxian LU
- Publication Type:Journal Article
- Keywords:
Receptors, thyrotropin;
Peptide fragments;
Immune system
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the characterization of thyrotropin receptor (TSHR) and its active fragment TSHR aa352-366 as immunogens in BALB/c mice. METHODS: BALB/c mice were injected peritoneally with TSHR aa352-366-KLH (hemocyanin from keyhole limpets) and the mixture of TSHR aa352-366-KLH and guinea pig TSHR every 15 days, respectively. The levels of thyroid hormones and TSHR antibodies and TSHR mRNA were measured, and the pathological changes of thyroid tissue were observed. RESULTS: In the group injected with TSHR aa352-366-KLH, the serum levels of TT_3 and TT_4 decreased (P
