Development and evaluation for volume overload-induced and pressure overload-induced cardiac hypertrophy in rats
- VernacularTitle:容量负荷和压力负荷型心脏肥大大鼠模型的建立及评价
- Author:
Minli ZHANG
;
Han XIAO
;
Yan BAI
;
Youyi ZHANG
;
Zhaoping LI
- Publication Type:Journal Article
- Keywords:
Cardiomegaly;
Rats;
Echocardiography;
Volume overload;
Pressure overload
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the evaluations for the structure and function of the hypertrophic hearts induced by volume overload or pressure overload in rats. METHODS: Volume overload-induced cardiac hypertrophy was established by abdominal aortacaval fistula (ACF) and pressure overload-induced cardiac hypertrophy was developed by constriction of aorta (CA). The cardiac structure and function were analyzed by echocardiography, hemodynamic determination, heart weight measurement and histological examination. RESULTS: Heart weight of rats in all the operated groups was increased compared to the sham-operated groups. In 1-week ACF group, the internal diameter (0.67?0.03)cm vs (0.60?0.02)cm, P
