Irbesartan suppresses expression of VCAM-1 and ICAM-1 in myocardial ischemia-reperfusion areas in rabbits
- VernacularTitle:伊贝沙坦抑制兔心肌缺血/再灌注ICAM-1和VCAM-1的表达
- Author:
Xingsan LI
;
Yufeng CHEN
;
Hong WEN
;
Daoye LIANG
- Publication Type:Journal Article
- Keywords:
Reperfusion injury;
Vascular cell adhesion molecule-1;
Intercellular adhesion molecule-1;
Irbesartan
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of irbesartan on acute myocardial ischemia-reperfusion injury and on expression of ICAM-1 and VCAM-1 in myocardial ischemia-reperfusion areas in rabbits. METHODS: Anterior descending branch of left coronary artery (LAD) was ligated in ischemia-reperfusion (IR) group but not in the sham group. Rabbits of IR group were subjected to 60 min of LAD occlusion, and 360 min of reperfusion. In the treated group, the rabbits were given irbesartan until the trial ended. Then, all rabbits were killed and tissue samples were removed from IR areas. After disposed with routine histological methods and stained with hematoxylin and eosin (HE), these samples were examined by light microscopy. The expression of ICAM-1 and VCAM-1 were also investigated by employing immunohistochemical SP method in the tissue samples. RESULTS: Degree of damage in cardiocytes and of neutrophil infiltration were more serious in IR group than those in sham group (P
