Effect of hypoxia on persistent sodium current in ventricular myocytes from 3-week infarcted rat heart
- VernacularTitle:缺氧对急性心肌梗死后3周大鼠心室肌细胞持续性钠电流的影响
- Author:
Peihua ZHANG
;
Jihua MA
;
Antao LUO
- Publication Type:Journal Article
- Keywords:
Sodium current;
Myocardial infarction;
Anoxia;
Myocardium
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of hypoxia on persistent sodium current (I_Nap ) in single ventricular myocyte isolated from acute myocardial infarction (AMI) heart of rats and to study the mechanisms of cardiac arrhythmias that occur after AMI. METHODS: AMI model was induced by ligating the left anterior descending coronary artery in rats. The whole-cell patch clamp technique was used to record the current in epicardial myocytes in infarcted region from rats at 3 week after AMI. RESULTS: In normoxic conditions, the current density of I_ Nap in cardiomyocytes of fake operation (FO) and AMI hearts was 0.144?0.022 pA/pF (n=9), 0.121?0.013 pA/pF (n=9,P
