p53,ki-67 and bcl-2 expression in breast cancer and its relation to neoadjuvant chemotherapy
- VernacularTitle:乳腺癌p53,ki-67和bcl-2的表达与新辅助化疗的关系
- Author:
Yongwei RUAN
;
Xing JIN
;
Hongyan MA
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/pathol;
Gene Expression;
p53
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of p53,ki-67 and bcl-2 expression in breast cancer with the clinical response to neoadjuvant chemotherapy,and search for biological markers to guide therapy and predict prognosis.Methods The expression of the p53,ki67 and bcl-2 was examined by immunohistochemical(assay) in samples of breast cancer tissue which taken from 118 cases of operable breast cancer patients.The relationship between p53,ki-67 and bcl-2 and the effect of neoadjuvant chemotherapy was analyzed by(chi-square) test.Results The overall response rate to neoadjuvant chemotherapy was 68.6%.Patients with expression of ki-67 were more likely to respond to treatment.The effect of neoadjuvant chemotherapy had a significantly negative correlation with p53 expression.There was no significant difference between the response to neoadjuvant chemotherapy and bcl-2 expression.Expression of p53 protein was correlated with low(expression) of bet-2.Expression of p53 and ki-67 protein was significantly related.Conclusions The(results) indicated that p53 and Ki-67 expressions are strong prognostic molecular markers that can be a guide for neoadjuvant chemotherapy and prediction of prognosis for patients with breast cancer.
