Expression and clinical significance of osteopotin in calcified breast tissue
- VernacularTitle:乳腺钙化组织中骨桥蛋白的表达及其临床意义
- Author:
Jinliang HUAN
;
Qiang WANG
;
Li XING
;
Xianju QIN
;
Wangkou MA
;
Yubing PENG
;
Zhiguang GAO
- Publication Type:Journal Article
- Keywords:
Breast Neoplasms/etiol;
Calcification,Pathologic;
Osteopontin
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of osteopontin(OPN) mRNA in breast tissues containing microcalcifications and the significance of OPN in tumor pathogenesis and metastasis of breast cancer.Methods The expression of OPNmRNA in 128 samples of tissues of breast lesions and adjacent breast tissues and 9 samples of metastatic lymph nodes were examined.Results The expression of OPNmRNA was highest in(calcified) foci of breast cancer tissues and in metastatic lynph nodes,lower in calcified foci of benign breast tissues and lowest in breast tissues adjacent to breast cancer and in benign tissues without calcification.The differences between the defferent tissues were significant(all P
