Effects of hyperoxic-hyperosmotic sodium chloride solution on blood lactate and arterial blood gas in rabbits with hemorrhagic shock
- VernacularTitle:高渗氯化钠高氧液对失血性休克家兔血乳酸和动脉血气的影响
- Author:
Kun LIU
;
Xihou LIN
- Publication Type:Journal Article
- Keywords:
Shock,Hemorrhagic/drug ther;
Hyperoxic-Hyperosmotic Sodium Chloride Solution/ther use;
Lactic Acid/blood;
Oxygen/blood
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of hyperoxic-hyperosmotic sodium chloride solution(HHSCS) on arterial blood gas and blood lactate in rabbits with hemorrhagic shock, and evaluate the HHSCS effects on hemorrhagic shock resuscitation.Methods Hemorrhagic shock models were induced in 30 male rabbits.The median arterial pressure(MAP) was declined to 40mmHg within 10 minutes,then maintained for 60(minutes).The animals were then randomly divided into 3 groups:normal saline hyperoxic solution(NSO)group,hyperosmotic sodium chloride solution(HS)group and HHSCS group.Sixty minutes later,NSO,HS or HHSCS 6ml/kg was infused intravenously in 5 minutes.Heart rate(HR) 、respiratory rate(RR)、 MAP and urine drops(UD) before shock and after fluid infusion were recorded;blood lactate(BL) and blood gas were measured before shock,60min after shock,and 30min,60min,120min postinfusion.Finally,the(rabbits) were killed by bleeding,the lungs were observed in autopsy,and the lung coefficient was measured.Results HS and HHSCS more effectively raised MAP,enhanced heart function,and increased UD than NSO.HHSCS group significantly reduced BL.At 60,120min after infusion,SaO_2 in HHSCS group was(significantly) higher than that in HS group and NSO group(P
