Role and significance of nuclear factor-?B activity in systemic inflammtory response syndrome
- VernacularTitle:核因子?B在全身炎症反应综合征中的预警作用
- Author:
Yuehong YAN
;
Xiaoli JING
;
Yimin CHEN
;
Yan CHEN
- Publication Type:Journal Article
- Keywords:
Systemic inflammatory response syndrome;
Nuclear factor-?B;
Multiple organ dysfunction syndrome
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the change and role of nuclear factor-kappa B(NF-?B) activity and tumor necrosis factor-alpha(TNF-?) level in patients with systemic inflammatory response syndrome(SIRS).Methods Eighty patients with SIRS were studied.The NF-?B activity in monocytes and the level of TNF-? in serum was measured.The state of illness was estimated by APACHEⅡ score.Results There was significant difference for the activity of NF-?B in patients with SIRS compared with the control group.The NF-?B activity,TNF-? level and APACHEⅡ score are higher in both resuscitation multiple organ dysfunction syndrome(MODS) group and death group than the non-MODS group and survival group correspondingly(P
