Diagnosis value of PP65 antigenemia assay in febrile children with cytomegalovirus infection
- VernacularTitle:PP65抗原血症检测法在发热患儿巨细胞病毒感染中的诊断价值
- Author:
Yanfeng LU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
PP65 antigenemia assay;
Cytomegalovirus infection
- From:
Chinese Journal of Postgraduates of Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate diagnosis value of PP65 antigenaemia assay(AA) on cytomegalovirus(CMV) infection in febrile children.Method One hundred and twenty-eight febrile children with febrile duration between one to two weeks,their blood preparations and urine aliquots were screened,indirect IF staining(antigen PP65),ELISA(CMV-IgM) and light microscope(urinary cytomegalic inclusion).Three methods above mentioned were used in all patients.Result The positive rate of PP65 antigenaemia,CMV-IgM and urinary cytomegalic inclusion was 17.2%,8.6%,6.3%,respectively.The positive coincidence rate of PP65 antigen with CMV-IgM and PP65 antigen with urinary cytomegalic inclusion was 50%(11/22),36%(8/22),respectively.Nineteen childrens antigenaemia PP65 became negative with patient′s condition improved.Three children′s PP65 antigenaemia remained positive,when they were clinic cured.Two of them became negative after two weeks and one after three weeks.Conclusion Antigenaemia PP65 is effective in early diagnosis of active CMV infection,predicting patient′s condition and providing early intervention and treatment.
