Application value of serum thyroid peroxidase in screening thyroid dysfunction in pregnancy
- VernacularTitle:过氧化物酶抗体在妊娠甲状腺功能紊乱发生中的诊断价值
- Author:
Zhijie ZENG
;
Tang JIANG
;
Wenting OUYANG
- Publication Type:Journal Article
- Keywords:
Peroxidases;
Autoantibodies;
Thyroid diseases;
Autoimmune diseases;
Pregnancy complications
- From:
International Journal of Laboratory Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the clinical value of serum thyroid peroxidase (TPOAb) in screening thyroid dysfunction in pregnancy.Methods The concentration of serum TPOAb and TSH(thyroid-stimulating hormone) was detected by MEIA and CMIA in 75 cases of pregnant women with thyroid disfunction,and 145 cases of pregnant women without tyhroid dysfunction (as control group).Results There were significant differences in both TSH and TPOAb levels between pregnant women with and without thyroid dysfunction(P0.05). So the normal serum TSH could not completely exclude the thyroid dysfunction in pregnant women.Conclusion TPOAb can be used as a prenatal screening marker for early diagnosis of thyroid dysfunction in pregnancy. From the diagnostic point, TSH can not completely substitute for TPOAb and the abnormal TPOAb can indicate the possibility and risk for autoimmune thyroid disease in pregnant women.
