Expression of IL-18R? on CD4+ T cells from children with Mycoplasma pneumoniae
- VernacularTitle:肺炎支原体肺炎患儿外周血CD4~+T淋巴细胞表面IL-18R?的表达
- Author:
Yingjian CHEN
;
Xiaoming SUN
;
Chengjin HU
- Publication Type:Journal Article
- Keywords:
Pneumoniae,mycoplasma;
Antigens,CD4;
Interleukin-18;
T-lymphocyte subsets;
Receptors,interleukin
- From:
International Journal of Laboratory Medicine
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of IL-18R? expression on CD4+ T cells in peripheral blood (PB) of children with Mycoplasma pneumoniae pneumonia (MPP).Methods T cell subtype CD3/CD4/CD8 and expression of IL-18R? on CD4+ T cells in PB from 35 children with MPP and 15 age- and sex-matched control subjects was determined by flow cytometry.Results Compared with that of healthy control, CD3+ and CD4+ positive cells in MPP children were decreased (P0.05).Conclusion There exists cell-mediated immune function disorders and Th1/Th2 imbalance in children with MPP. Th1 immune response is dominant in acute-stage MPP.
