Influence of MSCs Transplant on Ventricle Reconstruction in Mini Pig Model of Acute Myocardial Infarction
- VernacularTitle:骨髓间质干细胞移植对急性心肌梗死模型香猪心室重构的影响研究
- Author:
Yingjia XU
;
Weihua WU
;
Ritai HUANG
;
Hongsheng ZHU
- Publication Type:Journal Article
- Keywords:
MSCs;
Cellular transplant;
Acute myocardial infarction;
Mini pig;
Ventricular reconstruction
- From:
China Pharmacy
1991;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE: To study the influence of auto messenchymal stem cells(MSCs)transplant into the infracted area on the ventricle reconstruction in mini pig model of acute myocardial infarction. METHODS: The bone marrow of mini pig was collected and centrifuged in vitro for MSCs. Then after cultivation, transformation and labeling MSCs were injected into the ligated left anterior descending coronary artery and myocardium of mini pig,while the control group was administered with DMEM of the same dose. Doppler ultrasonography was performed separately at 3 weeks and 6 weeks. RESULTS: The left ventricular ejection fraction, shortening fraction, lateral thickening , and interventricular thickening in the experimental group were significantly improved, as compared with the control group, while the ventricular chamber in the experimental group was smaller than that in the control group. CONCLUSION: MSCs transplant can help to regenerate the myocardial issue in the infarcted area, thicken the myocardium, lessen the thinningz and cardiac muscle chamber, hence to slow down the process of ventricular reconstruction .
